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Avoid eating too much fruit and drinking fruit juices as these will interfere with the enzymes and they will increase the possibility of acquiring the side effects caused by the medication.
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Patent litigator Adam Cooke is also recommended.
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DURATION-2, a head-to-head comparative study of exenatide once weekly against sitagliptin or pioglitazone is a 26-week, double-blinded, phase 3, superiority study involving 491 patients whose diabetes was suboptimally controlled on metformin.
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Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P 2007 Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin.
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These changes came into effect in 2005, so Novartis' patent application waited in a "mailbox" with others until then, under procedures that India instituted to manage the transition.
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In 2008, Novartis withdrew its request for FDA approval.
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